Recombinant:Article Title: Taxane chemotherapy promotes response to TIM-3 checkpoint blockade via STING-mediated ER stress and HMGB1 secretion.
Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER Chemicals, peptides, and recombinant proteins 10× Tris-Buffered Saline (TBS) Bio-Rad Cat# 1706435 4–15% Mini-PROTEAN® TGXTM Precast Protein Gels, 12-well Bio-Rad Cat# 4561085 Antimicrobial Reagent Invivogen Cat# ant-noc BD Cytofix fixation buffer BD Biosciences Cat# 554655 BD Perm/Wash Buffer BD Biosciences Cat# 554723 Niraparib Selleck Chemicals Cat# S2741 Olaparib Selleck Chemicals Cat# S1060 Rucaparib Selleck Chemicals Cat# S4948 Bovine Serum Albumin FisherScientific Cat# BP1600-100 DAPI (4′,6-Diamidino-2-Phenylindole, Dilactate) Biolegend Cat# 422801 DMEM high glucose (4.5g/L) Thermo Fisher Cat# 11965118 DMSO FisherScientific Cat# BP231-100 DMXAA Invivogen Cat# tlrl-dmx Doxorubicin pfizer 0069-3030-20 5-Fluoro-2′-deoxyuridine 5′-monophosphate sodium salt,∼85% Sigma-Aldrich F3503-5MG Fetal bovine serum albumin Peak Serum Cat# PS-FB1 Fungin Antifungal agent Invivogen Cat# ant-fn-1 Hygromycin B Thermo Fisher Cat# 10687010 Trans-Blot® TurboTM Mini PVDF Transfer Packs Bio-Rad Cat#1704156EDU Opti-MEM Thermofisher Cat# 31985062 Penicillin/streptomycin Thermo Fisher Cat# 15140-122 Pierce BCA Protein assay Thermofisher Cat# 23227 PierceTM RIPA Buffer Thermofisher Cat# 89900 polyethylenimine (PEI) 25kDa Polysciences Cat# 23966-2 Precision Plus ProteinTM Dual Color Standards Bio-Rad Cat# 1610374 Puromycin Thermo Fisher Cat# A1113803 Paclitaxel Alvogen 47781-59307-0 Paclitaxel Teva 0703-3213-01 Paclitaxel Actavis 45963-613-56 Docetaxel Meitheal 71288-144-08 Docetaxel Pfizer 00409-0367-01 Docetaxel Armas Pharmaceuticals 7248-0214-01 Gemcitabine Armas Pharmaceuticals 72485-0221-02 Cisplatin Accord Healthcare 16729-0288-11 Cyclophosphamide Baxter 10019-0955-01 TrypLE Thermo Fisher Cat# 12604021 Tween 20 FisherScientific Cat# BP337-500 Zombie NIR Fixable Viability dye BioLegend Cat# 423105 R-Universal Epitope Recovery Buffer Fisher Scientific Cat# 50-192-6580 EverBriteTM Hardset Mounting Medium Biotium Cat# 23003 Corning Matrigel GFR/LDEV-Free Fisher Scientific Cat# CB-40230 BioReagent N-acetyl-L-cysteine, Powder, ≥99% (TLC), Suitable for cell culture Sigma-Aldrich Cat# A9165-5G Tunicamycin from Streptomyces sp. Millipore Sigma Cat# T7765-1MG M62812 TLR4 inhibitor Fisher Scientific Cat# 570510 GLX481304 NOX2/4i Sigma-Aldrich Cat# SML3192-5MG Cytochalasin B MedChemExpress Cat# HY-16928 (Continued on next page) e3 Cell Reports Medicine 7, 102788, May 19, 2026 Article ll OPEN ACCESS
Saline:Article Title: Taxane chemotherapy promotes response to TIM-3 checkpoint blockade via STING-mediated ER stress and HMGB1 secretion.
Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER Chemicals, peptides, and recombinant proteins 10× Tris-Buffered Saline (TBS) Bio-Rad Cat# 1706435 4–15% Mini-PROTEAN® TGXTM Precast Protein Gels, 12-well Bio-Rad Cat# 4561085 Antimicrobial Reagent Invivogen Cat# ant-noc BD Cytofix fixation buffer BD Biosciences Cat# 554655 BD Perm/Wash Buffer BD Biosciences Cat# 554723 Niraparib Selleck Chemicals Cat# S2741 Olaparib Selleck Chemicals Cat# S1060 Rucaparib Selleck Chemicals Cat# S4948 Bovine Serum Albumin FisherScientific Cat# BP1600-100 DAPI (4′,6-Diamidino-2-Phenylindole, Dilactate) Biolegend Cat# 422801 DMEM high glucose (4.5g/L) Thermo Fisher Cat# 11965118 DMSO FisherScientific Cat# BP231-100 DMXAA Invivogen Cat# tlrl-dmx Doxorubicin pfizer 0069-3030-20 5-Fluoro-2′-deoxyuridine 5′-monophosphate sodium salt,∼85% Sigma-Aldrich F3503-5MG Fetal bovine serum albumin Peak Serum Cat# PS-FB1 Fungin Antifungal agent Invivogen Cat# ant-fn-1 Hygromycin B Thermo Fisher Cat# 10687010 Trans-Blot® TurboTM Mini PVDF Transfer Packs Bio-Rad Cat#1704156EDU Opti-MEM Thermofisher Cat# 31985062 Penicillin/streptomycin Thermo Fisher Cat# 15140-122 Pierce BCA Protein assay Thermofisher Cat# 23227 PierceTM RIPA Buffer Thermofisher Cat# 89900 polyethylenimine (PEI) 25kDa Polysciences Cat# 23966-2 Precision Plus ProteinTM Dual Color Standards Bio-Rad Cat# 1610374 Puromycin Thermo Fisher Cat# A1113803 Paclitaxel Alvogen 47781-59307-0 Paclitaxel Teva 0703-3213-01 Paclitaxel Actavis 45963-613-56 Docetaxel Meitheal 71288-144-08 Docetaxel Pfizer 00409-0367-01 Docetaxel Armas Pharmaceuticals 7248-0214-01 Gemcitabine Armas Pharmaceuticals 72485-0221-02 Cisplatin Accord Healthcare 16729-0288-11 Cyclophosphamide Baxter 10019-0955-01 TrypLE Thermo Fisher Cat# 12604021 Tween 20 FisherScientific Cat# BP337-500 Zombie NIR Fixable Viability dye BioLegend Cat# 423105 R-Universal Epitope Recovery Buffer Fisher Scientific Cat# 50-192-6580 EverBriteTM Hardset Mounting Medium Biotium Cat# 23003 Corning Matrigel GFR/LDEV-Free Fisher Scientific Cat# CB-40230 BioReagent N-acetyl-L-cysteine, Powder, ≥99% (TLC), Suitable for cell culture Sigma-Aldrich Cat# A9165-5G Tunicamycin from Streptomyces sp. Millipore Sigma Cat# T7765-1MG M62812 TLR4 inhibitor Fisher Scientific Cat# 570510 GLX481304 NOX2/4i Sigma-Aldrich Cat# SML3192-5MG Cytochalasin B MedChemExpress Cat# HY-16928 (Continued on next page) e3 Cell Reports Medicine 7, 102788, May 19, 2026 Article ll OPEN ACCESS
Bicinchoninic Acid Protein Assay:Article Title: Taxane chemotherapy promotes response to TIM-3 checkpoint blockade via STING-mediated ER stress and HMGB1 secretion.
Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER Chemicals, peptides, and recombinant proteins 10× Tris-Buffered Saline (TBS) Bio-Rad Cat# 1706435 4–15% Mini-PROTEAN® TGXTM Precast Protein Gels, 12-well Bio-Rad Cat# 4561085 Antimicrobial Reagent Invivogen Cat# ant-noc BD Cytofix fixation buffer BD Biosciences Cat# 554655 BD Perm/Wash Buffer BD Biosciences Cat# 554723 Niraparib Selleck Chemicals Cat# S2741 Olaparib Selleck Chemicals Cat# S1060 Rucaparib Selleck Chemicals Cat# S4948 Bovine Serum Albumin FisherScientific Cat# BP1600-100 DAPI (4′,6-Diamidino-2-Phenylindole, Dilactate) Biolegend Cat# 422801 DMEM high glucose (4.5g/L) Thermo Fisher Cat# 11965118 DMSO FisherScientific Cat# BP231-100 DMXAA Invivogen Cat# tlrl-dmx Doxorubicin pfizer 0069-3030-20 5-Fluoro-2′-deoxyuridine 5′-monophosphate sodium salt,∼85% Sigma-Aldrich F3503-5MG Fetal bovine serum albumin Peak Serum Cat# PS-FB1 Fungin Antifungal agent Invivogen Cat# ant-fn-1 Hygromycin B Thermo Fisher Cat# 10687010 Trans-Blot® TurboTM Mini PVDF Transfer Packs Bio-Rad Cat#1704156EDU Opti-MEM Thermofisher Cat# 31985062 Penicillin/streptomycin Thermo Fisher Cat# 15140-122 Pierce BCA Protein assay Thermofisher Cat# 23227 PierceTM RIPA Buffer Thermofisher Cat# 89900 polyethylenimine (PEI) 25kDa Polysciences Cat# 23966-2 Precision Plus ProteinTM Dual Color Standards Bio-Rad Cat# 1610374 Puromycin Thermo Fisher Cat# A1113803 Paclitaxel Alvogen 47781-59307-0 Paclitaxel Teva 0703-3213-01 Paclitaxel Actavis 45963-613-56 Docetaxel Meitheal 71288-144-08 Docetaxel Pfizer 00409-0367-01 Docetaxel Armas Pharmaceuticals 7248-0214-01 Gemcitabine Armas Pharmaceuticals 72485-0221-02 Cisplatin Accord Healthcare 16729-0288-11 Cyclophosphamide Baxter 10019-0955-01 TrypLE Thermo Fisher Cat# 12604021 Tween 20 FisherScientific Cat# BP337-500 Zombie NIR Fixable Viability dye BioLegend Cat# 423105 R-Universal Epitope Recovery Buffer Fisher Scientific Cat# 50-192-6580 EverBriteTM Hardset Mounting Medium Biotium Cat# 23003 Corning Matrigel GFR/LDEV-Free Fisher Scientific Cat# CB-40230 BioReagent N-acetyl-L-cysteine, Powder, ≥99% (TLC), Suitable for cell culture Sigma-Aldrich Cat# A9165-5G Tunicamycin from Streptomyces sp. Millipore Sigma Cat# T7765-1MG M62812 TLR4 inhibitor Fisher Scientific Cat# 570510 GLX481304 NOX2/4i Sigma-Aldrich Cat# SML3192-5MG Cytochalasin B MedChemExpress Cat# HY-16928 (Continued on next page) e3 Cell Reports Medicine 7, 102788, May 19, 2026 Article ll OPEN ACCESS
Thin Layer Chromatography:Article Title: Taxane chemotherapy promotes response to TIM-3 checkpoint blockade via STING-mediated ER stress and HMGB1 secretion.
Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER Chemicals, peptides, and recombinant proteins 10× Tris-Buffered Saline (TBS) Bio-Rad Cat# 1706435 4–15% Mini-PROTEAN® TGXTM Precast Protein Gels, 12-well Bio-Rad Cat# 4561085 Antimicrobial Reagent Invivogen Cat# ant-noc BD Cytofix fixation buffer BD Biosciences Cat# 554655 BD Perm/Wash Buffer BD Biosciences Cat# 554723 Niraparib Selleck Chemicals Cat# S2741 Olaparib Selleck Chemicals Cat# S1060 Rucaparib Selleck Chemicals Cat# S4948 Bovine Serum Albumin FisherScientific Cat# BP1600-100 DAPI (4′,6-Diamidino-2-Phenylindole, Dilactate) Biolegend Cat# 422801 DMEM high glucose (4.5g/L) Thermo Fisher Cat# 11965118 DMSO FisherScientific Cat# BP231-100 DMXAA Invivogen Cat# tlrl-dmx Doxorubicin pfizer 0069-3030-20 5-Fluoro-2′-deoxyuridine 5′-monophosphate sodium salt,∼85% Sigma-Aldrich F3503-5MG Fetal bovine serum albumin Peak Serum Cat# PS-FB1 Fungin Antifungal agent Invivogen Cat# ant-fn-1 Hygromycin B Thermo Fisher Cat# 10687010 Trans-Blot® TurboTM Mini PVDF Transfer Packs Bio-Rad Cat#1704156EDU Opti-MEM Thermofisher Cat# 31985062 Penicillin/streptomycin Thermo Fisher Cat# 15140-122 Pierce BCA Protein assay Thermofisher Cat# 23227 PierceTM RIPA Buffer Thermofisher Cat# 89900 polyethylenimine (PEI) 25kDa Polysciences Cat# 23966-2 Precision Plus ProteinTM Dual Color Standards Bio-Rad Cat# 1610374 Puromycin Thermo Fisher Cat# A1113803 Paclitaxel Alvogen 47781-59307-0 Paclitaxel Teva 0703-3213-01 Paclitaxel Actavis 45963-613-56 Docetaxel Meitheal 71288-144-08 Docetaxel Pfizer 00409-0367-01 Docetaxel Armas Pharmaceuticals 7248-0214-01 Gemcitabine Armas Pharmaceuticals 72485-0221-02 Cisplatin Accord Healthcare 16729-0288-11 Cyclophosphamide Baxter 10019-0955-01 TrypLE Thermo Fisher Cat# 12604021 Tween 20 FisherScientific Cat# BP337-500 Zombie NIR Fixable Viability dye BioLegend Cat# 423105 R-Universal Epitope Recovery Buffer Fisher Scientific Cat# 50-192-6580 EverBriteTM Hardset Mounting Medium Biotium Cat# 23003 Corning Matrigel GFR/LDEV-Free Fisher Scientific Cat# CB-40230 BioReagent N-acetyl-L-cysteine, Powder, ≥99% (TLC), Suitable for cell culture Sigma-Aldrich Cat# A9165-5G Tunicamycin from Streptomyces sp. Millipore Sigma Cat# T7765-1MG M62812 TLR4 inhibitor Fisher Scientific Cat# 570510 GLX481304 NOX2/4i Sigma-Aldrich Cat# SML3192-5MG Cytochalasin B MedChemExpress Cat# HY-16928 (Continued on next page) e3 Cell Reports Medicine 7, 102788, May 19, 2026 Article ll OPEN ACCESS
Cell Culture:Article Title: Taxane chemotherapy promotes response to TIM-3 checkpoint blockade via STING-mediated ER stress and HMGB1 secretion.
Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER Chemicals, peptides, and recombinant proteins 10× Tris-Buffered Saline (TBS) Bio-Rad Cat# 1706435 4–15% Mini-PROTEAN® TGXTM Precast Protein Gels, 12-well Bio-Rad Cat# 4561085 Antimicrobial Reagent Invivogen Cat# ant-noc BD Cytofix fixation buffer BD Biosciences Cat# 554655 BD Perm/Wash Buffer BD Biosciences Cat# 554723 Niraparib Selleck Chemicals Cat# S2741 Olaparib Selleck Chemicals Cat# S1060 Rucaparib Selleck Chemicals Cat# S4948 Bovine Serum Albumin FisherScientific Cat# BP1600-100 DAPI (4′,6-Diamidino-2-Phenylindole, Dilactate) Biolegend Cat# 422801 DMEM high glucose (4.5g/L) Thermo Fisher Cat# 11965118 DMSO FisherScientific Cat# BP231-100 DMXAA Invivogen Cat# tlrl-dmx Doxorubicin pfizer 0069-3030-20 5-Fluoro-2′-deoxyuridine 5′-monophosphate sodium salt,∼85% Sigma-Aldrich F3503-5MG Fetal bovine serum albumin Peak Serum Cat# PS-FB1 Fungin Antifungal agent Invivogen Cat# ant-fn-1 Hygromycin B Thermo Fisher Cat# 10687010 Trans-Blot® TurboTM Mini PVDF Transfer Packs Bio-Rad Cat#1704156EDU Opti-MEM Thermofisher Cat# 31985062 Penicillin/streptomycin Thermo Fisher Cat# 15140-122 Pierce BCA Protein assay Thermofisher Cat# 23227 PierceTM RIPA Buffer Thermofisher Cat# 89900 polyethylenimine (PEI) 25kDa Polysciences Cat# 23966-2 Precision Plus ProteinTM Dual Color Standards Bio-Rad Cat# 1610374 Puromycin Thermo Fisher Cat# A1113803 Paclitaxel Alvogen 47781-59307-0 Paclitaxel Teva 0703-3213-01 Paclitaxel Actavis 45963-613-56 Docetaxel Meitheal 71288-144-08 Docetaxel Pfizer 00409-0367-01 Docetaxel Armas Pharmaceuticals 7248-0214-01 Gemcitabine Armas Pharmaceuticals 72485-0221-02 Cisplatin Accord Healthcare 16729-0288-11 Cyclophosphamide Baxter 10019-0955-01 TrypLE Thermo Fisher Cat# 12604021 Tween 20 FisherScientific Cat# BP337-500 Zombie NIR Fixable Viability dye BioLegend Cat# 423105 R-Universal Epitope Recovery Buffer Fisher Scientific Cat# 50-192-6580 EverBriteTM Hardset Mounting Medium Biotium Cat# 23003 Corning Matrigel GFR/LDEV-Free Fisher Scientific Cat# CB-40230 BioReagent N-acetyl-L-cysteine, Powder, ≥99% (TLC), Suitable for cell culture Sigma-Aldrich Cat# A9165-5G Tunicamycin from Streptomyces sp. Millipore Sigma Cat# T7765-1MG M62812 TLR4 inhibitor Fisher Scientific Cat# 570510 GLX481304 NOX2/4i Sigma-Aldrich Cat# SML3192-5MG Cytochalasin B MedChemExpress Cat# HY-16928 (Continued on next page) e3 Cell Reports Medicine 7, 102788, May 19, 2026 Article ll OPEN ACCESS
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